Department of Biochemistry and Molecular Pharmacology

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  1. Jiang X, Totrov M, Li W, Sampson JM, Williams C, Lu H, Wu X, Lu S, Wang S, Zolla-Pazner S, Kong XP. Rationally Designed Immunogens Targeting HIV-1 gp120 V1V2 Induce Distinct Conformation-Specific Antibody Responses in Rabbits. J. Virol. 2017; 90(24):11007-19. PMID 27707920.
  2. Balasubramanian P, Kumar R, Williams C, Itri V, Wang S, Lu S, Hessell AJ, Haigwood NL, Sinangil F, Higgins KW, Liu L, Li L, Nyambi P, Gorny MK, Totrov M, Nadas A, Kong XP, Zolla-Pazner S, Hioe CE. Differential induction of anti-V3 crown antibodies with cradle- and ladle-binding modes in response to HIV-1 envelope vaccination. Vaccine. 2017; 35(10):1464-73. PMID 28185743.
  3. Colleen CR, Mayr L, Nanfack AJ, Banin AN, Tuen M, Pan R, Jiang X, Kong XP, Kirkpatrick AR, Bruno D, Martens CA, Sykora LA, Porcella SF, Redd AD, Quinn TC, Nyambi PN, Dür R. Contrasting antibody responses to intrasubtype superinfection with CRF02_AG. Plos ONE. 2017; 12(3):e0173705. PMID 28288209.
  4. Bode NJ, Chan KW, Kong XP, Pearson MM. Distinct Residues Contribute to Motility Repression and Autoregulation in the Proteus mirabilis Fimbria-Associated Transcriptional Regulator AtfJ. J. Bacteriol. 2016; 198(15):2100-12. PMID 27246571.
  5. Wu X, Kong XP. Antigenic landscape of the HIV-1 envelope and new immunological concepts defined by HIV-1 broadly neutralizing antibodies. Curr. Opin. Immunol. 2016; 42:56-64. PMID 27289425.
  6. Zolla-Pazner S, Cohen SS, Boyd D, Kong XP, Seaman M, Nussenzweig M, Klein F, Overbaugh J, Totrov M. Structure/Function Studies Involving the V3 Region of the HIV-1 Envelope Delineate Multiple Factors That Affect Neutralization Sensitivity. J. Virol. 2016; 90(2):636-49. PMID 26491157.
  7. Killikelly A, Benson MA, Ohneck EA, Sampson JM, Jakoncic J, Spurrier B, Torres VJ, Kong XP. Structure-based functional characterization of repressor of toxin (Rot), a central regulator of Staphylococcus aureus virulence. J. Bacteriol. 2015; 197(1):188-200. PMID 25331435.
  8. Kumar R, Pan R, Upadhyay C, Mayr L, Cohen S, Wang XH, Balasubramanian P, Nádas A, Seaman MS, Zolla-Pazner S, Gorny MK, Kong XP, Hioe CE. Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody 2424 with Neutralizing Activity against HIV-1 JRFL. J. Virol. 2015; 89(17):9090-102. PMID 26109728.
  9. Pan R, Chen Y, Vaine M, Hu G, Wang S, Lu S, Kong XP. Structural analysis of a novel rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region critical for receptor and co-receptor binding. Emerg Microbes Infect. 2015; 4(7):e44. PMID 26251831.
  10. Pan R, Gorny MK, Zolla-Pazner S, Kong XP. The V1V2 Region of HIV-1 gp120 Forms a Five-Stranded Beta Barrel. J. Virol. 2015; . PMID 26018158.
  11. Shen G, Upadhyay C, Zhang J, Pan R, Zolla-Pazner S, Kong XP, Hioe CE. Rationally Targeted Mutations at the V1V2 Domain of the HIV-1 Envelope to Augment Virus Neutralization by Anti-V1V2 Monoclonal Antibodies. PLoS ONE. 2015; 10(10):e0141233. PMID 26491873.
  12. Cardozo T, Wang S, Jiang X, Kong XP, Hioe C, Krachmarov C. Vaccine focusing to cross-subtype HIV-1 gp120 variable loop epitopes. Vaccine. 2014; 32(39):4916-24. PMID 25045827.
  13. Evering TH, Kamau E, St Bernard L, Farmer CB, Kong XP, Markowitz M. Single genome analysis reveals genetic characteristics of Neuroadaptation across HIV-1 envelope. Retrovirology. 2014; 11:65. PMID 25125210.
  14. Killikelly A, Benson MA, Ohneck EA, Sampson JM, Jakoncic J, Spurrier B, Torres VJ, Kong XP. Structure-based functional characterization of Repressor of Toxin (Rot), a central regulator of Staphylococcus aureus virulence. J. Bacteriol. 2014; . PMID 25331435.
  15. Spurrier B, Sampson J, Gorny MK, Zolla-Pazner S, Kong XP. Functional Implications of the Binding Mode of a Human Conformation-Dependent V2 Monoclonal Antibody against HIV. J. Virol. 2014; 88(8):4100-12. PMID 24478429.
  16. Zolla-Pazner S, Edlefsen PT, Rolland M, Kong XP, deCamp A, Gottardo R, Williams C, Tovanabutra S, Sharpe-Cohen S, Mullins JI, deSouza MS, Karasavvas N, Nitayaphan S, Rerks-Ngarm S, Pitisuttihum P, Kaewkungwal J, O'Connell RJ, Robb ML, Michael NL, Kim JH, Gilbert P. Vaccine-induced Human Antibodies Specific for the Third Variable Region of HIV-1 gp120 Impose Immune Pressure on Infecting Viruses. EBioMedicine. 2014; 1(1):37-45. PMID 25599085.
  17. Killikelly A, Zhang HT, Spurrier B, Williams C, Gorny MK, Zolla-Pazner S, Kong XP. Thermodynamic signatures of the antigen binding site of mAb 447-52D targeting the third variable region of HIV-1 gp120. Biochemistry. 2013; 52(36):6249-57. PMID 23944979.
  18. Mayr LM, Cohen S, Spurrier B, Kong XP, Zolla-Pazner S. Epitope Mapping of Conformational V2-specific Anti-HIV Human Monoclonal Antibodies Reveals an Immunodominant Site in V2. PLoS ONE. 2013; 8(7):e70859. PMID 23923028.
  19. Murphy MK, Yue L, Pan R, Boliar S, Sethi A, Tian J, Pfafferot K, Karita E, Allen SA, Cormier E, Goepfert PA, Borrow P, Robinson JE, Gnanakaran S, Hunter E, Kong XP, Derdeyn CA. Viral escape from neutralizing antibodies in early subtype A HIV-1 infection drives an increase in autologous neutralization breadth. PLoS Pathog. 2013; 9(2):e1003173. PMID 23468623.
  20. O'Connell O, Repik A, Reeves JD, Gonzalez-Perez MP, Quitadamo B, Anton ED, Duenas-Decamp M, Peters P, Lin R, Zolla-Pazner S, Corti D, Wallace A, Wang S, Kong XP, Lu S, Clapham PR. Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism. J. Virol. 2013; 87(1):187-98. PMID 23055568.
  21. Pan R, Sampson JM, Chen Y, Vaine M, Wang S, Lu S, Kong XP. Rabbit anti-HIV-1 monoclonal antibodies raised by immunization can mimic the antigen-binding modes of antibodies derived from HIV-1 infected humans. J. Virol. 2013; . PMID 23864637.
  22. Chiu YN, Sampson JM, Jiang X, Zolla-Pazner SB, Kong XP. Skin tattooing as a novel approach for DNA vaccine delivery. J Vis Exp. 2012; 68. PMID 23117298.
  23. Gorny MK, Pan R, Williams C, Wang XH, Volsky B, O'Neal T, Spurrier B, Sampson JM, Li L, Seaman MS, Kong XP, Zolla-Pazner S. Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individuals. Virology. 2012; 427(2):198-207. PMID 22402248.
  24. Pan J, Chen Q, Willenbring D, Yoshida K, Tillman T, Kashlan OB, Cohen A, Kong XP, Xu Y, Tang P. Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine. Nat Commun. 2012; 3:714. PMID 22395605.
  25. Pan J, Chen Q, Willenbring D, Mowrey D, Kong XP, Cohen A, Divito CB, Xu Y, Tang P. Structure of the pentameric ligand-gated ion channel GLIC bound with anesthetic ketamine. Structure. 2012; 20(9):1463-9. PMID 22958642.
  26. Gorny MK, Sampson J, Li H, Jiang X, Totrov M, Wang XH, Williams C, O'Neal T, Volsky B, Li L, Cardozo T, Nyambi P, Zolla-Pazner S, Kong XP. Human anti-V3 HIV-1 monoclonal antibodies encoded by the VH5-51/VL lambda genes define a conserved antigenic structure. PLoS ONE. 2011; 6(12):e27780. PMID 22164215.
  27. Spurrier B, Sampson JM, Totrov M, Li H, O'Neal T, Williams C, Robinson J, Gorny MK, Zolla-Pazner S, Kong XP. Structural analysis of human and macaque mAbs 2909 and 2.5B: implications for the configuration of the quaternary neutralizing epitope of HIV-1 gp120. Structure. 2011; 19(5):691-9. PMID 21565703.
  28. Zolla-Pazner S, Kong XP, Jiang X, Cardozo T, Nádas A, Cohen S, Totrov M, Seaman MS, Wang S, Lu S. Cross-clade HIV-1 neutralizing antibodies induced with V3-scaffold protein immunogens following priming with gp120 DNA. J. Virol. 2011; 85(19):9887-98. PMID 21795338.
  29. Jiang X, Burke V, Totrov M, Williams C, Cardozo T, Gorny MK, Zolla-Pazner S, Kong XP. Conserved structural elements in the V3 crown of HIV-1 gp120. Nat. Struct. Mol. Biol. 2010; 17(8):955-61. PMID 20622876.
  30. Li HG, Huang PL, Zhang D, Sun Y, Chen HC, Zhang J, Huang PL, Kong XP, Lee-Huang S. A new activity of anti-HIV and anti-tumor protein GAP31: DNA adenosine glycosidase--structural and modeling insight into its functions. Biochem. Biophys. Res. Commun. 2010; 391(1):340-5. PMID 19913503.
  31. Totrov M, Jiang X, Kong XP, Cohen S, Krachmarov C, Salomon A, Williams C, Seaman MS, Abagyan R, Cardozo T, Gorny MK, Wang S, Lu S, Pinter A, Zolla-Pazner S. Structure-guided design and immunological characterization of immunogens presenting the HIV-1 gp120 V3 loop on a CTB scaffold. Virology. 2010; 405(2):513-23. PMID 20663531.
  32. Burke V, Williams C, Sukumaran M, Kim SS, Li H, Wang XH, Gorny MK, Zolla-Pazner S, Kong XP. Structural basis of the cross-reactivity of genetically related human anti-HIV-1 mAbs: implications for design of V3-based immunogens. Structure. 2009; 17(11):1538-46. PMID 19913488.
  33. Jaglin XH, Poirier K, Saillour Y, Buhler E, Tian G, Bahi-Buisson N, Fallet-Bianco C, Phan-Dinh-Tuy F, Kong XP, Bomont P, Castelnau-Ptakhine L, Odent S, Loget P, Kossorotoff M, Snoeck I, Plessis G, Parent P, Beldjord C, Cardoso C, Represa A, Flint J, Keays DA, Cowan NJ, Chelly J. Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat. Genet. 2009; 41(6):746-52. PMID 19465910.
  34. Liu Z, Gosser Y, Baker PJ, Ravee Y, Lu Z, Alemu G, Li H, Butterfoss GL, Kong XP, Gross R, Montclare JK. Structural and functional studies of Aspergillus oryzae cutinase: enhanced thermostability and hydrolytic activity of synthetic ester and polyester degradation. J. Am. Chem. Soc. 2009; 131(43):15711-6. PMID 19810726.
  35. Wang H, Min G, Glockshuber R, Sun TT, Kong XP. Uropathogenic E. coli adhesin-induced host cell receptor conformational changes: implications in transmembrane signaling transduction. J. Mol. Biol. 2009; 392(2):352-61. PMID 19577575.
  36. Wu XR, Kong XP, Pellicer A, Kreibich G, Sun TT. Uroplakins in urothelial biology, function, and disease. Kidney Int. 2009; 75(11):1153-65. PMID 19340092.
  37. Georgescu RE, Kim SS, Yurieva O, Kuriyan J, Kong XP, O'Donnell M. Structure of a sliding clamp on DNA. Cell. 2008; 132(1):43-54. PMID 18191219.
  38. Georgescu RE, Yurieva O, Kim SS, Kuriyan J, Kong XP, O'Donnell M. Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp. Proc. Natl. Acad. Sci. U.S.A. 2008; 105(32):11116-21. PMID 18678908.
  39. Tian G, Kong XP, Jaglin XH, Chelly J, Keays D, Cowan NJ. A pachygyria-causing alpha-tubulin mutation results in inefficient cycling with CCT and a deficient interaction with TBCB. Mol. Biol. Cell. 2008; 19(3):1152-61. PMID 18199681.
  40. Wang H, Liang FX, Kong XP. Characteristics of the phagocytic cup induced by uropathogenic Escherichia coli. J. Histochem. Cytochem. 2008; 56(6):597-604. PMID 18347076.
  41. Kreplak L, Wang H, Aebi U, Kong XP. Atomic force microscopy of Mammalian urothelial surface. J. Mol. Biol. 2007; 374(2):365-73. PMID 17936789.
  42. Xu CF, Wang H, Li D, Kong XP, Neubert TA. Selective enrichment and fractionation of phosphopeptides from peptide mixtures by isoelectric focusing after methyl esterification. Anal. Chem. 2007; 79(5):2007-14. PMID 17249638.
  43. Laptenko O, Kim SS, Lee J, Starodubtseva M, Cava F, Berenguer J, Kong XP, Borukhov S. pH-dependent conformational switch activates the inhibitor of transcription elongation. EMBO J. 2006; 25(10):2131-41. PMID 16628221.
  44. Min G, Wang H, Sun TT, Kong XP. Structural basis for tetraspanin functions as revealed by the cryo-EM structure of uroplakin complexes at 6-A resolution. J. Cell Biol. 2006; 173(6):975-83. PMID 16785325.
  45. Stanhill A, Haynes CM, Zhang Y, Min G, Steele MC, Kalinina J, Martinez E, Pickart CM, Kong XP, Ron D. An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity. Mol. Cell. 2006; 23(6):875-85. PMID 16973439.
  46. Tu L, Kong XP, Sun TT, Kreibich G. Integrity of all four transmembrane domains of the tetraspanin uroplakin Ib is required for its exit from the ER. J. Cell. Sci. 2006; 119(Pt 24):5077-86. PMID 17158912.
  47. Xie B, Zhou G, Chan SY, Shapiro E, Kong XP, Wu XR, Sun TT, Costello CE. Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia. J. Biol. Chem. 2006; 281(21):14644-53. PMID 16567801.
  48. Min G, Zhou G, Schapira M, Sun TT, Kong XP. Structural basis of urothelial permeability barrier function as revealed by Cryo-EM studies of the 16 nm uroplakin particle. J. Cell. Sci. 2003; 116(Pt 20):4087-94. PMID 12972502.
  49. Min G, Stolz M, Zhou G, Liang F, Sebbel P, Stoffler D, Glockshuber R, Sun TT, Aebi U, Kong XP. Localization of uroplakin Ia, the urothelial receptor for bacterial adhesin FimH, on the six inner domains of the 16 nm urothelial plaque particle. J. Mol. Biol. 2002; 317(5):697-706. PMID 11955018.
  50. Liang FX, Riedel I, Deng FM, Zhou G, Xu C, Wu XR, Kong XP, Moll R, Sun TT. Organization of uroplakin subunits: transmembrane topology, pair formation and plaque composition. Biochem. J. 2001; 355(Pt 1):13-8. PMID 11256943.
  51. Zhou G, Mo WJ, Sebbel P, Min G, Neubert TA, Glockshuber R, Wu XR, Sun TT, Kong XP. Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: evidence from in vitro FimH binding. J. Cell. Sci. 2001; 114(Pt 22):4095-103. PMID 11739641.
  52. Zhang Z, Zhang R, Joachimiak A, Schlessinger J, Kong XP. Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation. Proc. Natl. Acad. Sci. U.S.A. 2000; 97(14):7732-7. PMID 10884405.
  53. Sham HL, Zhao C, Stewart KD, Betebenner DA, Lin S, Park CH, Kong XP, Rosenbrook W, Herrin T, Madigan D, Vasavanonda S, Lyons N, Molla A, Saldivar A, Marsh KC, McDonald E, Wideburg NE, Denissen JF, Robins T, Kempf DJ, Plattner JJ, Norbeck DW. A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease. J. Med. Chem. 1996; 39(2):392-7. PMID 8558507.
  54. Kempf DJ, Marsh KC, Denissen JF, McDonald E, Vasavanonda S, Flentge CA, Green BE, Fino L, Park CH, Kong XP. ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc. Natl. Acad. Sci. U.S.A. 1995; 92(7):2484-8. PMID 7708670.
  55. Krishna TS, Kong XP, Gary S, Burgers PM, Kuriyan J. Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA. Cell. 1994; 79(7):1233-43. PMID 8001157.
  56. Krishna TS, Fenyö D, Kong XP, Gary S, Chait BT, Burgers P, Kuriyan J. Crystallization of proliferating cell nuclear antigen (PCNA) from Saccharomyces cerevisiae. J. Mol. Biol. 1994; 241(2):265-8. PMID 7914545.
  57. Kong XP, Onrust R, O'Donnell M, Kuriyan J. Three-dimensional structure of the beta subunit of E. coli DNA polymerase III holoenzyme: a sliding DNA clamp. Cell. 1992; 69(3):425-37. PMID 1349852.
  58. O'Donnell M, Kuriyan J, Kong XP, Stukenberg PT, Onrust R. The sliding clamp of DNA polymerase III holoenzyme encircles DNA. Mol. Biol. Cell. 1992; 3(9):953-7. PMID 1358275.
  59. Kuriyan J, Kong XP, Krishna TS, Sweet RM, Murgolo NJ, Field H, Cerami A, Henderson GB. X-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4-A resolution. Proc. Natl. Acad. Sci. U.S.A. 1991; 88(19):8764-8. PMID 1924336.
  60. Ziff RM, Kong XP, Cohen EG. Lorentz lattice-gas and kinetic-walk model. Phys. Rev., A. 1991; 44(4):2410-2428. PMID 9906223.
  61. Kong XP, Cohen EG. Anomalous diffusion in a lattice-gas wind-tree model. Phys. Rev., B Condens. Matter. 1989; 40(7):4838-4845. PMID 9992480.